NLRP3 inflammasome mediates interleukin‐1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in …

MJ Kang, SG Jo, DJ Kim, JH Park - Immunology, 2017 - Wiley Online Library
… , but not lung epithelial cells and fibroblasts (L929), could produce huge amounts of IL-1β
at … NLRP3 inflammasome is involved in IL-1β production in neutrophils in response to A. …

[HTML][HTML] NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection

…, P Kumar, TP Lim, TT Tan, AL Kwa, A Mortellaro… - Mucosal …, 2018 - Elsevier
Nlrp3 −/− mice infection models, we further show that while NLRP3 inflammasome pathway
contributes … concentration of interleukin- (IL-1β) (a marker of inflammasome activation) …

… protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary inflammation

Y Li, C Peng, D Zhao, L Liu, B Guo, M Shi, Y Xiao… - Microbial …, 2021 - Elsevier
… As the innate immune system is the first line of host defence … caused by ompA-mediated
release of ROS activates the NLRP3baumannii infection leads to activation of the NLRP3

Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii

G Burgio, FJ Li, L Starrs, A Mathur, DE Tuipulotu… - 2024 - researchsquare.com
baumannii 19 activate the NLRP3 inflammasome complex … of the pro- 62 inflammatory
cytokines pro-interleukin- (pro-IL-… the 260 contribution of type I IFN signalling to inflammasome

Caspase-11 plays a protective role in pulmonary Acinetobacter baumannii infection

W Wang, Y Shao, S Li, N Xin, T Ma, C Zhao… - … and immunity, 2017 - Am Soc Microbiol
… -1/interleukin (IL-1β) pathway, independent of canonical … In addition to the NLRP3
inflammasome, our in vitro study … in BALF and lung tissue from caspase-11 −/− mice were much …

GBP1 promotes killing of multidrug-resistant Acinetobacter baumannii and promotes host protection via interferon signalling and inflammasome activation

FJ Li, L Starrs, A Mathur, D Enosi Tuipulotu, SM Man… - bioRxiv, 2022 - biorxiv.org
baumannii activate the NLRP3 inflammasome complex … cleavage of the pro-inflammatory
cytokines pro-interleukin- (pro-IL-1β) … recruitment in Nlrp3 -/- mice might have contributed to …

[HTML][HTML] Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264. 7 …

Z An, J Su - Microbes and Infection, 2019 - Elsevier
… pyroptosis by NLRP3 inflammasome-mediated IL-1β … baumannii-caused pulmonary damage
in mice with NLRP3, … release, which leads to pyroptosis of RAW264.7 cells. We thought that …

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

Y Li, X Guo, C Hu, Y Du, C Guo, D Wang… - Cell Death & …, 2018 - nature.com
… Multidrug-resistant Acinetobacter baumannii, a common … NLRP3 inflammasome activation,
and potentially contributedmediated NLRP3 inflammasome activation response to A. …

OmpA Protein-Deficient Acinetobacter baumannii Outer Membrane Vesicles Trigger Reduced Inflammatory Response

J Skerniškytė, E Karazijaitė, A Lučiūnaitė… - Pathogens, 2021 - mdpi.com
baumannii OMVs substantially contributes to the … to J774 mice macrophages and A549
human lung epithelium cells … activate NLRP3 inflammasome [30]. In addition to the formation of …

[HTML][HTML] Cathelicidin-related antimicrobial peptide contributes to host immune responses against pulmonary infection with Acinetobacter baumannii in mice

MJ Kang, AR Jang, JY Park, JH Ahn, TS Lee… - Immune …, 2020 - ncbi.nlm.nih.gov
… how the innate immune response mediates the resistance of … of innate immune cells in CRAMP
−/− mice than in WT mice. In … baumannii in neutrophils by inhibiting NLRP3 inflammasome